Principal Investigator

Dr. R.Berni Canani has developed an interdisciplinary research team and a highly integrated research clinical program to better understand the pathogenic mechanisms of GI diseases and provide the best care for children affected by these disorders. The main study aim of the program is focused on the identification of best strategies for the management of pediatric patients affected by food allergies and food intolerances, and for the identification of innovative strategies to induce immune tolerance in children affected by food allergy. A bench to bedside approach is used to investigate pathophysiological basis of pediatric food-induced diseases including animal models, peripheral blood cells culture from children, epigenetics biomarkers involved in IgE- and in non-IgE-mediated food allergy, gut microbiota structure and function analysis. His studies on gut microbiome, oral tolerance and immunonutrition have already been translated into novel concepts and lead to a paradigm shift in the pathogenesis and treatment of food allergy and of other pediatric diseases.